heterogeneous nuclear ribonucleoprotein-A1 (hnRNP-A1)

Function: - role in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm & may modulate splice site selection - Arg-194, Arg-206 & Arg-225 are dimethylated, probably to asymmetric dimethylarginine - identified in the spliceosome C complex Structure: contains 2 RRM domain (RNA recognition motif)s Compartment: - nucleus, cytoplasm - shuttles continuously between the nucleus & the cytoplasm along with mRNA - component of ribonucleosomes Alternative splicing: named isoforms=3

Specific

hnRNP core protein-A1A hnRNP core protein-A1B

General

heterogeneous nuclear ribonucleoprotein (hnRNP) phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 372 aa MW = 39 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Globular A {4-94} MOTIF: Ser phosphorylation site {S4} Ser phosphorylation site {S6} RNP motif NAME: RNP motif SITE: 14-97 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S91} Globular B {95-185} MOTIF: Ser phosphorylation site {S95} RNP motif NAME: RNP motif SITE: 105-184 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Thr phosphorylation site {T138} Ser phosphorylation site {S142} Tyr phosphorylation site {Y167} glycine-rich region {195-372} MOTIF: binding site SITE: 218-240 FOR-BINDING-OF: ribonucleic acid Ser phosphorylation site {S311} M9 {320-357} Ser phosphorylation site {S338} Tyr phosphorylation site {Y347} Ser phosphorylation site {S368}

Database Correlations

OMIM 164017 UniProt P09651 Pfam PF00076 Entrez Gene 3178 Kegg hsa:3178

References

UniProt :accession P09651