histamine N-methyltransferase (HNMT)

Function: - inactivates histamine by N-methylation - role in degrading histamine & in regulating airway response to histamine S-adenosyl-L-methionine + histamine S-adenosyl-L-homocysteine + N-methylhistamine Structure: - monomer - belongs to the methyltransferase superfamily, HNMT family Compartment: cytoplasm Polymorphism: - variant Ile-105 has a reduced activity & seems to be linked with a susceptibility to asthma

General

N-methyltransferase phosphoprotein

Properties

SIZE: entity length = 292 aa MW = 33 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S3} Ser phosphorylation site {S10} Ser phosphorylation site {S18} binding site SITE: 28-28 FOR-BINDING-OF: Substrate binding site SITE: 60-60 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 89-89 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 94-94 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 120-120 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 142-142 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 283-283 FOR-BINDING-OF: Substrate

Database Correlations

OMIM 605238 MORBIDMAP 605238 UniProt P50135 Entrez Gene 3176 Kegg hsa/hsa00340 ENZYME 2.1.1.8

References

UniProt :accession P50135