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non-histone chromosomal protein HMG-14; high-mobility group nucleosome-binding domain-containing protein 1 (HMGN1 HMG14)
Function:
- binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA & the histone octamer
- may be involved in the process which maintains transcribable genes in an unique chromatin conformation
- inhibits phosphorylation of nucleosomal histones H3 & H2A by RPS6KA5/MSK1 & RPS6KA3/RSK2 (putative)
- phosphorylation on Ser-21 & Ser-25 weakens binding to nucleosomes & increases the rate of H3 phosphorylation
- phosphorylation favors cytoplasmic localization
Structure: belongs to the HMGN family
Compartment:
- nucleus, cytoplasm
- cytoplasmic enrichment upon phosphorylation.
- the RNA edited version localizes to the nucleus
RNA editing:
- partially edited
- a new initiator Met may be created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 45 amino acids
- the RNA edited version is called ET-HMGN1
General
DNA-binding protein
high-mobility group [HMG] protein
phosphoprotein
Properties
SIZE: entity length = 100 aa
MW = 11 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S7}
Ser phosphorylation site {S8}
Ser phosphorylation site {S21}
Ser phosphorylation site {S25}
Thr phosphorylation site {T70}
Thr phosphorylation site {T81}
Ser phosphorylation site {S86}
Ser phosphorylation site {S89}
Ser phosphorylation site {S99}
Database Correlations
OMIM 163920
UniProt P05114
Pfam PF01101
Entrez Gene 3150
Kegg hsa:3150
References
- UniProt :accession P05114
- Louie DF
Phosphorylation and subcellular redistribution of high
mobility group proteins 14 and 17, analyzed by mass
spectrometry.
Protein Sci. 2000 Jan;9(1):170-9
PMID: 10739259