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H2.0 (Drosophila)-like homeobox protein; homeobox protein HLX1; homeobox protein HB24, (HLX, HLX1)
Function:
- transcription factor required for
a) TBX21/T-bet-dependent maturation of Th1 cells
b) maintenance of Th1-specific gene expression
- involved in embryogenesis & hematopoiesis
Structure:
- belongs to the H2.0 homeobox family
- contains 1 homeobox DNA-binding domain
Compartment: nucleus (putative)
Expression:
- low level in normal B & T-cells
- high level in activated lymphocytes & monocytes
- also found in thymus, tonsil, bone marrow, developing vessels, & fetal brain
General
homeobox protein
Properties
SIZE: entity length = 488 aa
MW = 51 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 92-169
MOTIF: proline residue (SEVERAL)
glutamine-rich region {125-137}
MOTIF: glutamine residue (SEVERAL)
homeodomain
SITE: 276-335
serine-rich region {366-454}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 142995
UniProt Q14774
Pfam PF00046
Kegg hsa:3142
References
- UniProt :accession Q14774
- OMIM :accession 142995
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=PHOX2B