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HLA-B*5801 allele

Indications: - assess risk of hypersensitivity to allopurinol [1] Clinical significance: - the HLA-B*5801 allele is associated with allopurinol-induced Stevens-Johnson syndrome & toxic epidermal necrolysis in the Han-Chinese population

General

HLA-B genotyping

References

  1. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline information for allopurinol and HLA-B. https://www.pharmgkb.org/guideline/PA166105003
  2. ARUP Consult: HLA-B*58:01 Genotyping, Allopurinol Hypersensitivity https://arupconsult.com/ati/HLA-B58%253A01%2520Genotyping