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HLA-B*1502 allele

Indications: - epilepsy, neuropathic pain - assessment of risk for Stevens-Johnson syndrome & toxic epidermal necrolysis - carbamazepine, lamotrigine or phenytoin therapy in high-risk populations* * Han Chinese at highest risk * persons from Vietnam, Cambodia, the Reunion Islands, Thailand, India (specifically Hindus), Malaysia, & Hong Kong Clinical significance: - carbamazepine, lamotrigine & phenytoin induced Stevens-Johnson syndrome & toxic epidermal necrolysis is associated with HLA-B*1502 allele in high-risk populations

Related

HLA B75 (HLA B*1502)

General

HLA-B genotyping

References

  1. Mayo Clinic Laboratories: HLA-B 1502 Genotype, Carbamazepine Hypersensitivity http://www.mayomedicallaboratories.com/test-catalog/Overview/89347
  2. Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012
  3. Hung SI, Chung WH, Liu ZS et al Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics. 2010 Mar;11(3):349-56 PMID: 20235791