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HLA-B*1301 allele

Indications: - assess risk of hypersensitivity to dapsone [1] Clinical significance: - increased risk of adverse cutaneous reactions in Han Chinese & Tai populations - screening for HLA-B*1301 allele recommended prior to dapsone therapy in Asians [1] Notes: - no corresponding Loinc found

General

HLA-B genotyping

References

  1. Tangamornsuksan W, Lohitnavy M. Association Between HLA-B*1301 and Dapsone-Induced Cutaneous Adverse Drug Reactions. A Systematic Review and Meta-analysis. JAMA Dermatol. 2018 Mar 14. PMID: 29541744
  2. ARUP Consul: 2006986 / HLA-B Genotype include a note specifying antigen of interest (HLA-B*1301) http://www.arupconsult.com