Search
HLA B75 (HLA B*1502)
Pathology:
- carbamazepine & phenytoin induced Stevens-Johnson syndrome & toxic epidermal necrolysis is associated with HLA-B*1502 allele in Thai population, Han Chines, Asians, & South Asian Indians
Properties
GENERAL: HLA-B antigen
RELATED: HLA-B*1502 allele
COMPARTMENT: plasma membrane
SUBUNITS: MHC class I alpha chain
MOTIF: glycosylation site
immunoglobulin superfamily domain
transmembrane domain
beta-2-microglobulin
MOTIF: signal sequence {1-20}
immunoglobulin superfamily domain {25-113}
MOTIF: cysteine residue {C45}
MODIFICATION: cysteine residue {C100}
cysteine residue {C100}
MODIFICATION: cysteine residue {C45}
References
- Wikipedia: HLA-B75
http://en.wikipedia.org/wiki/HLA-B75
- Locharernkul C et al
Carbamazepine and phenytoin induced Stevens-Johnson syndrome
is associated with HLA-B*1502 allele in Thai population
Epilepsia 2008 49(12):2087
PMID: 18637831