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histone methyltransferase (HMT) complex; SET1 complex
Function:
- probably several different complexes
- one specifically methylates Lys-4 of histone H3, but not if the neighboring Lys-9 residue is already methylated (SET1 complex)
- another specifically mediates dimethylation & trimethylation of Lys-4 of histone H3
Structure:
- subunits:
- (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L & CXXC1/CFP1
- RBBP5, ASH2L, SET1, SET2 & KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 & KMT2B/MLL
Related
histone methyltransferase complex (GO:0035097)
Specific
menin-associated histone methyltransferase complex
Set1/Ash2 histone methyltransferase (HMT) complex
General
histone N-methyltransferase
molecular complex
Properties
COMPARTMENT: cell nucleus
MOTIF: active site
SUBUNITS: retinoblastoma binding protein 5
COMPARTMENT: cell nucleus
MOTIF: WD repeat {22-63}
WD repeat {64-103}
WD repeat {148-188}
MOTIF: Ser phosphorylation site {S182}
Thr phosphorylation site {T193}
WD repeat {196-235}
WD repeat {249-291}
MOTIF: Thr phosphorylation site {T252}
WD repeat {293-331}
Ser phosphorylation site {S350}
Ser phosphorylation site {S388}
Ser phosphorylation site {S389}
Ser phosphorylation site {S497}
Set1/Ash2 histone methyltransferase complex subunit ASH2
COMPARTMENT: cell nucleus
MOTIF: Zn finger C4-type
SITE: 117-150
EFFECTOR-BOUND: Zn+2
B30.2/SPRY {360-583}
histone-lysine N-methyltransferase H3 lysine-4 specific SET1
COMPARTMENT: cell nucleus
MOTIF: RNP motif
NAME: RNP motif
SITE: 84-172
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
serine-rich region {244-362}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 383-654
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S468}
Ser phosphorylation site {S470}
glutamate-rich region {899-1010}
MOTIF: glutamate residue (SEVERAL)
serine-rich region {1011-1062}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 1071-1194
MOTIF: proline residue (SEVERAL)
HCFC1-binding motif (HBM) {1299-1303}
glutamate-rich region {1334-1375}
MOTIF: glutamate residue (SEVERAL)
proline-rich region
SITE: 1403-1417
MOTIF: proline residue (SEVERAL)
SET domain {1567-1689}
post-SET domain {1691-1707}
histone-lysine N-methyltransferase SETD2
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 166-247
MOTIF: proline residue (SEVERAL)
arginine-rich region {385-456}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S1413}
AWS {1494-1548}
SET domain {1549-1671}
post-SET domain {1674-1690}
coiled coil {2117-2146}
Low charge region {2137-2366}
MOTIF: proline-rich region
SITE: 2149-2232
MOTIF: proline residue (SEVERAL)
glutamine-rich region {2266-2365}
MOTIF: glutamine residue (SEVERAL)
WW domain (W/rsp5/WWP domain) {2389-2422}
binding site
SITE: 2457-2564
FOR-BINDING-OF: RNA polymerase-2 L'
histone-lysine N-methyltransferase 2A
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {17-102}
MOTIF: serine residue (SEVERAL)
glycine-rich region {137-143}
Ser phosphorylation site {S153}
A+T hook
SITE: 169-180
Ser phosphorylation site {S197}
A+T hook
SITE: 217-227
A+T hook
SITE: 301-309
Ser phosphorylation site {S518}
proline-rich region
SITE: 561-564
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 568-571
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S680}
Thr phosphorylation site {T840}
Ser phosphorylation site {S926}
Ser phosphorylation site {S1056}
Zinc finger
NAME: Zinc finger
SITE: 1147-1195
EFFECTOR-BOUND: Zn+2
breakpoint {1334-1335}
breakpoint {1362-1363}
MOTIF: breakpoint {1362-1363}
breakpoint {1362}
breakpoint {1406-1407}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1431-1482
EFFECTOR-BOUND: Zn+2
MOTIF: breakpoint {1444-1445}
breakpoint {1444-1445}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1479-1533
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1566-1627
EFFECTOR-BOUND: Zn+2
Bromo; divergent {1703-1748}
Thr phosphorylation site {T1845}
Ser phosphorylation site {S1858}
FYR N-terminal {2018-2074}
Ser phosphorylation site {S2098}
Thr phosphorylation site {T2147}
Ser phosphorylation site {S2151}
Ser phosphorylation site {S2201}
Thr phosphorylation site {T2525}
proteolytic site {2666-2667}
proteolytic site {2718-2719}
9aaTAD {2847-2855}
Ser phosphorylation site {S2955}
Ser phosphorylation site {S3036}
Thr phosphorylation site {T3372}
Ser phosphorylation site {S3511}
Ser phosphorylation site {S3515}
FYR C-terminal {3666-3747}
arginine residue {3765}
SET domain {3829-3945}
MOTIF: binding site
SITE: 3839-3839
FOR-BINDING-OF: S-adenosylmethionine
binding site
SITE: 3841-3841
FOR-BINDING-OF: S-adenosylmethionine
binding site
SITE: 3883-3883
FOR-BINDING-OF: S-adenosylmethionine
S-adenosyl-L-methionine binding {3906-3907}
Zn+2-binding site
SITE: 3909-3909
post-SET domain {3953-3969}
MOTIF: Zn+2-binding site
SITE: 3957-3957
binding site
SITE: 3958-3958
FOR-BINDING-OF: S-adenosylmethionine
Zn+2-binding site
SITE: 3959-3959
Zn+2-binding site
SITE: 3964-3964
histone-lysine N-methyltransferase 2D
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S27}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 226-276
EFFECTOR-BOUND: Zn+2
cysteine-rich region {229-326}
MOTIF: RING-finger {229-274}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 273-323
EFFECTOR-BOUND: Zn+2
RING-finger {276-321}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
proline-rich region
SITE: 374-1197
MOTIF: proline residue (SEVERAL)
15 X 5 AA repeats of S/P-P-P-E/P-E/A {439-668}
consensus repeat {442-446}
consensus repeat {460-464}
consensus repeat {469-473}
consensus repeat {496-500}
consensus repeat {504-508}
consensus repeat {521-525}
consensus repeat {555-559}
consensus repeat {564-568}
consensus repeat {573-577}
consensus repeat {582-586}
consensus repeat {609-613}
consensus repeat {618-622}
consensus repeat {627-631}
consensus repeat {645-649}
consensus repeat {663-667}
arginine-rich region {1290-1328}
MOTIF: arginine residue (SEVERAL)
glutamate-rich region {1351-1355}
MOTIF: glutamate residue (SEVERAL)
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1377-1430
EFFECTOR-BOUND: Zn+2
cysteine-rich region {1397-1510}
MOTIF: Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1427-1477
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1504-1559
EFFECTOR-BOUND: Zn+2
MOTIF: RING-finger {1507-1557}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Ser phosphorylation site {S1606}
Ser phosphorylation site {S1671}
proline-rich region
SITE: 2107-2626
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S2274}
Ser phosphorylation site {S2309}
Ser phosphorylation site {S2311}
proline-rich region
SITE: 2385-2392
MOTIF: proline residue (SEVERAL)
coiled coil {2669-2707}
MOTIF: LXXLL motif 1 {2686-2690}
alanine-rich region {2707-2713}
MOTIF: alanine residue (SEVERAL)
glutamine-rich region {2811-2822}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 2862-2978
MOTIF: proline residue (SEVERAL)
LXXLL motif 2 {3038-3042}
Ser phosphorylation site {S3130}
Thr phosphorylation site {T3197}
Ser phosphorylation site {S3199}
coiled coil {3249-3282}
glutamine-rich region {3261-4275}
MOTIF: glutamine residue (SEVERAL)
coiled coil {3562-3614}
coiled coil {3714-3750}
coiled coil {3897-3975}
Ser phosphorylation site {S4215}
LXXLL motif 3 {4222-4236}
proline-rich region
SITE: 4241-4360
MOTIF: proline residue (SEVERAL)
LXXLL motif 4 {4253-4257}
Ser phosphorylation site {S4359}
LXXLL motif 5 {4463-4467}
Ser phosphorylation site {S4738}
Ser phosphorylation site {S4822}
proline-rich region
SITE: 4909-4977
MOTIF: proline residue (SEVERAL)
LXXLL motif 6 {4990-4994}
RING-finger {5092-5137}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
FYR N-terminal {5175-5235}
FYR C-terminal {5236-5321}
SET domain {5397-5513}
MOTIF: binding site
SITE: 5451-5451
FOR-BINDING-OF: S-adenosylmethionine
S-adenosyl-L-methionine binding {5474-5475}
Zn+2-binding site
SITE: 5477-5477
post-SET domain {5521-5537}
MOTIF: Zn+2-binding site
SITE: 5525-5525
Zn+2-binding site
SITE: 5527-5527
Zn+2-binding site
SITE: 5532-5532
histone-lysine N-methyltransferase MLL3
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 34-46
coiled coil {92-112}
Zinc finger
NAME: Zinc finger
SITE: 341-391
EFFECTOR-BOUND: Zn+2
MOTIF: RING-finger {344-389}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zinc finger
NAME: Zinc finger (3)
SITE: 388-520
EFFECTOR-BOUND: Zn+2
coiled coil {644-672}
Zinc finger
NAME: Zinc finger (3)
SITE: 957-1139
EFFECTOR-BOUND: Zn+2
coiled coil {1338-1366}
glutamine-rich region {1719-1796}
MOTIF: glutamine residue (SEVERAL)
coiled coil {1754-1787}
proline-rich region
SITE: 1834-2281
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 2412-2630
MOTIF: proline residue (SEVERAL)
glutamine-rich region {3012-3509}
MOTIF: glutamine residue (SEVERAL)
coiled coil {3054-3081}
coiled coil {3173-3272}
proline-rich region
SITE: 3277-3381
MOTIF: proline residue (SEVERAL)
coiled coil {3391-3433}
SET domain {4770-4891}
post-SET domain {4895-4911}
histone-lysine N-methyltransferase 2B
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
glycine-rich region {26-37}
A+T hook
SITE: 37-44
A+T hook
SITE: 110-117
proline-rich region
SITE: 248-255
MOTIF: proline residue (SEVERAL)
A+T hook
SITE: 357-365
acidic region {362-398}
MOTIF: acidic residue (SEVERAL)
proline-rich region
SITE: 402-771
MOTIF: proline residue (SEVERAL)
glutamine-rich region {808-812}
MOTIF: glutamine residue (SEVERAL)
Ser phosphorylation site {S821}
Ser phosphorylation site {S844}
Ser phosphorylation site {S861}
Zinc finger
NAME: Zinc finger
SITE: 959-1006
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S1032}
Ser phosphorylation site {S1035}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1201-1252
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1249-1303
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1335-1396
EFFECTOR-BOUND: Zn+2
FYR N-terminal {1727-1783}
Ser phosphorylation site {S1930}
proline-rich region
SITE: 1963-1970
MOTIF: proline residue (SEVERAL)
Thr phosphorylation site {T2068}
Ser phosphorylation site {S2070}
Thr phosphorylation site {T2083}
proline-rich region
SITE: 2251-2259
MOTIF: proline residue (SEVERAL)
FYR C-terminal {2411-2492}
SET domain {2575-2691}
MOTIF: binding site
SITE: 2585-2585
FOR-BINDING-OF: S-adenosylmethionine
binding site
SITE: 2587-2587
FOR-BINDING-OF: S-adenosylmethionine
binding site
SITE: 2629-2629
FOR-BINDING-OF: S-adenosylmethionine
binding site
SITE: 2652-2653
FOR-BINDING-OF: S-adenosylmethionine
Zn+2-binding site
SITE: 2655-2655
post-SET domain {2699-2715}
MOTIF: Zn+2-binding site
SITE: 2703-2703
binding site
SITE: 2704-2704
FOR-BINDING-OF: S-adenosylmethionine
Zn+2-binding site
SITE: 2705-2705
Zn+2-binding site
SITE: 2710-2710
References
UniProt :accession Q9Y5B6
Components
histone-lysine N-methyltransferase 2A; lysine N-methyltransferase 2A; ALL-1; CXXC-type zinc finger protein 7; myeloid/lymphoid or mixed-lineage leukemia protein 1; trithorax-like protein; zinc finger protein HRX; contains: MLL cleavage product N320; N-terminal cleavage product of 320 kDa; p320; contains: MLL cleavage product C180; C-terminal cleavage product of 180 kD; p180 (KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1)
histone-lysine N-methyltransferase 2B; lysine N-methyltransferase 2B; myeloid/lymphoid or mixed-lineage leukemia protein 4; trithorax homolog 2; WW domain-binding protein 7; WBP-7 (KMT2B, HRX2, KIAA0304, MLL2, MLL4, TRX2, WBP7)
histone-lysine N-methyltransferase 2D; lysine N-methyltransferase 2D; ALL1-related protein; myeloid/lymphoid or mixed-lineage leukemia protein 2 (KMT2D, ALR, MLL2, MLL4)
histone-lysine N-methyltransferase H3 lysine-4 specific SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET-domain-containing protein 1A (SETD1A, KIAA0339, SET1)
histone-lysine N-methyltransferase MLL3; homologous to ALR protein; lysine N-methyltransferase 2C; KMT2C; myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3, HALR, KIAA1506, KMT2C)
histone-lysine N-methyltransferase SETD2 (SET domain-containing protein 2, hSET2, Huntingtin-interacting protein HYPB, Huntingtin yeast partner B, Huntingtin-interacting protein 1, HIF-1, p231HBP, SETD2, HIF1, HYPB, KIAA1732, SET2, HSPC069)
retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3 (RBBP5, RBQ3)
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein, ASH2L)