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histone deacetylase (HDAC) core complex
Function:
- associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 & CHD4 to form the NuRD complex, or with SIN3, SAP18 & SAP30 to form the SIN3 HDAC complex
Structure:
- subunits include: HDAC1, HDAC2, RBBP4 & RBBP7
Related
histone deacetylase
histone deacetylase complex (GO:0000118)
General
molecular complex
Properties
SUBUNITS: histone deacetylase 1
COMPARTMENT: cell nucleus
MOTIF: Histone deacetylase {9-321}
MOTIF: histidine residue {H141}
Tyr phosphorylation site {Y221}
Ser phosphorylation site {S393}
Ser phosphorylation site {S421}
Ser phosphorylation site {S423}
binding site
FOR-BINDING-OF: retinoblastoma-associated protein
histone deacetylase 2
COMPARTMENT: cell nucleus
MOTIF: Histone deacetylase {9-322}
MOTIF: histidine residue {H142}
glycine-rich region {300-303}
Ser phosphorylation site {S394}
Ser phosphorylation site {S407}
Ser phosphorylation site {S422}
Ser phosphorylation site {S424}
histone-binding protein RBBP4
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
WD repeat {122-155}
WD repeat {175-206}
WD repeat {225-256}
WD repeat {271-302}
WD repeat {315-346}
WD repeat {372-403}
histone-binding protein RBBP7
COMPARTMENT: cell nucleus
MOTIF: WD repeat {121-152}
WD repeat {174-205}
WD repeat {224-255}
WD repeat {270-301}
WD repeat {314-345}
Ser phosphorylation site {S354}
WD repeat {371-402}
Ser phosphorylation site {S413}
Thr phosphorylation site {T416}
References
UniProt :accession Q13547
Component-of
sin3 repressor complex
Components
histone deacetylase 1 (reduced potassium dependency 3 [RPD3] homolog-like 1, HDAC1, RPD3L1)
histone deacetylase 2 (HDAC2)
histone-binding protein RBBP4; retinoblastoma-binding protein 4; RBBP-4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; CAF-1 subunit C; chromatin assembly factor I p48 subunit; CAF-I 48 kD subunit; CAF-I p48; nucleosome-remodeling factor subunit RBAP48 (RBBP4, RbAp48)
histone-binding protein RBBP7; retinoblastoma-binding protein 7; RBBP-7; retinoblastoma-binding protein p46; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46 (RBBP7, RBAP46, HAT2)