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histone deacetylase 1 (reduced potassium dependency 3 [RPD3] homolog-like 1, HDAC1, RPD3L1)
Function:
- see histone deacetylase
- part of the core histone deacetylase complex (HDAC complex)
- component of BHC histone deacetylase complex
- component of a mSin3A corepressor complex
- associates with the 9-1-1 complex
- interacts with HUS1
- found in a complex with DNMT3A & HDAC7
- interacts with BCOR, BRMS1L, DAXX, DNMT1, EP300, HCFC1, PCAF, PHB2, MIER1, JMJD2A/JHDM3A, MINT, NRIP1, RERE, SETDB1, SUV39H1, TGIF, TGIF2, UHRF1 & UHRF2
- interacts with the non-histone region of H2AFY. interacts with HDAC9
- interacts with BANP, CBFA2T3 & JARID1B
- interacts with SAP30L
- sumoylated on Lys-444 & Lys-476, which promotes enzymatic activity
- desumoylated by SENP1
- phosphorylation on Ser-421 & Ser-423 promotes enzymatic activity & interactions with NuRD complex & SIN3 complex
Structure:
- belongs to the histone deacetylase family, type 1 subfamily
Compartment: nucleus
Expression:
- ubiquitous
- expressed in heart, pancreas & testis > kidney & brain
Interactions
molecular events
Related
HDAC1/RPD3L1 gene
General
histone deacetylase
phosphoprotein
Properties
SIZE: entity length = 482 aa
MW = 55 kD
COMPARTMENT: cell nucleus
MOTIF: Histone deacetylase {9-321}
MOTIF: histidine residue {H141}
Tyr phosphorylation site {Y221}
Ser phosphorylation site {S393}
Ser phosphorylation site {S421}
Ser phosphorylation site {S423}
binding site
FOR-BINDING-OF: retinoblastoma-associated protein
References
- Taunton J et al
A mammalian histone deacetylase related to the yeast
transcriptional regulator Rpd3p.
Science 272:408-11, 1996
PMID: 8602529
- UniProt :accession Q13547
Component-of
histone deacetylase (HDAC) core complex
Databases & Figures
OMIM 601241
UniProt Q13547
Entrez Gene 3065
RB/E2F1 interactions