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HIRA protein (TUP1-like enhancer of split protein 1, HIRA, DGCR1, HIR, TUPLE1)
Function:
1) role in mechanisms of transcriptional regulation similar to that played by yeast HIR1 & HIR2 together
2) interacts with HIRIP3, NFU1/HIRIP5, histones H2B & H4, & PAX3
3) sumoylated
Structure:
1) belongs to the WD repeat HIR1 family.
2) contains 4 WD repeats
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- widely distributed
- expressed during embryogenesis
Pathology:
- role in etiology of DiGeorge syndrome
General
other protein
Properties
SIZE: MW = 112 kD
entity length = 1017 aa
COMPARTMENT: cell nucleus
MOTIF: WD repeat {68-98}
WD repeat {129-159}
WD repeat {172-202}
WD repeat {266-313}
MOTIF: nuclear translocation signal {267-286}
glutamine-rich region {408-412}
MOTIF: glutamine residue (SEVERAL)
binding site
SITE: 593-826
FOR-BINDING-OF: histone-H2B
MOTIF: nuclear translocation signal {628-645}
lysine-rich region {640-643}
MOTIF: lysine residue (SEVERAL)
binding site
SITE: 738-1017
FOR-BINDING-OF: histone H4
Database Correlations
OMIM 600237
UniProt P54198
PFAM correlations
References
UniProt :accession P54198