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homeodomain-interacting protein kinase 3; homolog of protein kinase YAK1; Fas-interacting serine/threonine protein kinase; FIST, androgen receptor-interacting nuclear protein kinase; ANPK (HIPK3, DYRK6, FIST3, PKY)
Function:
- negatively regulates apoptosis via FADD phosphorylation
- interacts with & stabilizes ligand-bound androgen receptor
- enhances androgen receptor-mediated transcription
- may act as a transcriptional corepressor for NK homeodomain transcription factors
- interacts with Nkx1-2, FAS & DAXX
- probably part of a complex consisiting of HIPK3, FAS & FADD
Compartment: nuclear & cytoplasmic
Expression:
- overexpressed in multidrug resistant cells
- highly expressed in heart & skeletal muscle
General
serine/threonine kinase
Properties
SIZE: MW = 134 kD
entity length = 1215 aa
COMPARTMENT: cytoplasm
cell nucleus
STATE: active state
MOTIF: kinase domain
SITE: 197-525
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 203-211
ATP-binding site
NAME: ATP-binding site
SITE: 226-226
aspartate residue {D322}
Tyr phosphorylation site {Y359}
binding site
SITE: 767-944
FOR-BINDING-OF: androgen receptor
MOTIF: binding site
SITE: 796-891
FOR-BINDING-OF: Fas antigen
binding site
SITE: 870-880
FOR-BINDING-OF: small ubiquitin-related modifier 1
serine-rich region {910-962}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 604424
UniProt Q9H422
Pfam PF00069
ENZYME 2.7.1.37
References
UniProt :accession Q9H422