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huntingtin-interacting protein 1-related protein; HIP1-related protein; huntingtin-interacting protein 12; HIP-12 (HIP1R, HIP12, KIAA0655)
Function:
- component of clathrin coated pits & vesicles
- interacts with actin
- binds 3-phosphoinositides (via ENTH domain)
- may act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis
- does not interact with huntingtin (putative)
- interacts with CLTB & huntingtin interacting protein 1 (HIP1
- homodimer; homodimerization promotes actin binding
Structure:
- binds F-actin via the talin-like I/LWEQ domain
- belongs to the SLA2 family
- contains 1 ENTH (epsin N-terminal homology) domain
- contains 1 I/LWEQ domain
Compartment:
- cytoplasm, perinuclear region, endomembrane system
- cytoplasmic vesicle, clathrin-coated vesicle membrane
- membrane-associated protein, mainly localized in the endocytic compartments & in the perinuclear region
Expression:
- brain, heart, kidney, pancreas, & liver, but not in lung or placenta
General
phosphoprotein
Properties
SIZE: entity length = 1068 aa
MW = 119 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: ENTH {23-151}
coiled coil {347-599}
I/LWEQ {771-1012}
MOTIF: Important for actin binding {867-924}
Ser phosphorylation site {S1017}
Database Correlations
OMIM 605613
UniProt O75146
PFAM correlations
Entrez Gene 9026
Kegg hsa:9026
References
- UniProt :accession O75146
- Entrez Gene :accession 9026