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high molecular weight kininogen in plasma (Fitzgerald factor assay)

Indications: - workup of coagulation disorder Clinical significance: - routine prolonged PTT evaluation finds no explanation - PTT is normal in the mixing study - factor VIII, factor IX, factor XI, & factor XII are normal - prothrombin time & plasma fibrinogen are normal - lupus anticoagulant assays are negative - if prekallikrein assays are normal, HMW kininogen assays may be considered

Related

high molecular weight [HMW] kininogen; alpha-2 thiol proteinase inhibitor (KNG1) low molecular weight kininogen in plasma

General

clinical coagulation test

References

  1. Coagulation Test Handbook: Prekallikrein http://mghlabtest.partners.org/coagbook/CO002600.htm