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high fat diet
Epidemiology:
- high fat diet associated with lower mortality than high carbohydrate diet [2]
Comparative biology:
- in mice, a high-fat diet induces PPAR-delta in intestinal stem cells & (non-stem cell) progenitor cells [1]
- enforced PPAR-delta signalling permits these progenitors to form in vivo tumurs after loss of the tumor suppressor APC [1]
Related
low carbohydrate diet; ketogenic diet (Atkin's diet, Eco-Atkin's diet)
Specific
high polyunsaturated fat diet
General
diet
References
- Beyaz S, Mana MD, Roper J et al
High-fat diet enhances stemness and tumorigenicity of
intestinal progenitors.
Nature 531:5358. March 3 2016
PMID: 26935695
http://www.nature.com/nature/journal/v531/n7592/full/nature17173.html
- Dehghan M, Mente A, Zhang X et al
Associations of fats and carbohydrate intake with cardiovascular
disease and mortality in 18 countries from five continents
(PURE): a prospective cohort study.
Lancet. Aug 29, 2017
PMID: 28864332
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32252-3/fulltext
- Ramsden CE, Domenichiello AF
PURE study challenges the definition of a healthy diet: but
key questions remain.
Lancet. Aug 29, 2017
PMID: 28864330
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32241-9/fulltext