serine/threonine protein kinase ICK; intestinal cell kinase; hICK; MAK-related kinase; MRK; laryngeal cancer kinase 2,; LCK2 (ICK, KIAA0936)

Function: - may play a role in cardiac development - phosphorylation at T14 or Y15 inactivates - phosphorylation at T157 & Y159 activates Compartment: cytoplasm Expression: - expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine & colon Pathology: - expressed in many cancer cell lines

General

membrane protein serine/threonine kinase

Properties

SIZE: MW = 71 kD entity length = 632 aa COMPARTMENT: cytoplasm MOTIF: kinase domain SITE: 4-284 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 10-18 Thr phosphorylation site {T14} Tyr phosphorylation site {Y15} ATP-binding site NAME: ATP-binding site SITE: 33-33 aspartate residue {D125} Thr phosphorylation site {T157} Tyr phosphorylation site {Y159} STATE: active state

Database Correlations

UniProt Q9UPZ9 Pfam PF00069 ENZYME 2.7.1.37

References

UniProt :accession Q9UPZ9