MyoD family inhibitor domain-containing protein (I-mfa domain- containing protein, HIC) (MDFIC)

Function: - modulates the expression from both cellular & viral promoters - down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat & Rev & impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta - stimulates activation of human T-cell leukemia virus type 1 (HTLV-1) LTR - binds to the axin complex, resulting in an increase in the level of free beta-catenin - affects axin regulation of the WNT & JNK signaling pathways - C-terminus interacts with HIV-1 Tat & Rev, AXIN1, the histidine-rich region of CCNT1/CYCLIN T & weakly with LEF1 Structure: - belongs to the MDFI family - cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm Compartment: - cytoplasm, nucleus, nucleolus - isoform 1 localizes to the nucleolus & also shows a granular distribution in cytoplasm - isoform 2 is predominantly distributed throughout cytoplasm, with only weak expression in nucleus Alternative splicing: named isoforms=2 Expression: - expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes),prostate, uterus & small intestine Note: initiates from GTG codon

Properties

SIZE: MW = 37 kD entity length = 355 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: alanine-rich region {6-34} MOTIF: alanine residue (SEVERAL) arginine-rich region {22-101} MOTIF: arginine residue (SEVERAL) nucleolar localization signal {45-63} cysteine-rich region {275-352}

References

UniProt :accession Q9P1T7