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chlorhexidine (Peridex, Hibiclens, Nolvasan, Bactigras, Arlacide H)

Tradename: Peridex, Hibiclens. Indications: 1) antibacterial dental rinse for treatment of oral cavity infections a) gingivitis b) aphthous stomatitis 2) soap for eradication of MRSA 3) prevention of ventilator-associated pneumonia [3] * does not reduce nosocomial infection in critically ill ICU patients [4] Dosage: 1) dental rinse (Peridex) a) swish 15 mL undiluted oral rinse around in mouth for 30 sec, then expectorate b) do NOT swallow c) use twice daily in the treatment of gingivitis d) precede use by brushing & flossing 2) topical agent for use on skin - QD-TID use Solution: - dental rinse: 0.12% with alcohol 11.6%. (480 mL) - Hibiclens (topical): 4%, 8 oz (OTC) Adverse effects: 1) staining of oral surfaces 2) change or reduction in taste 3) anaphylaxis (rare) [5] 4) FIRE risk ?? Mechanism of action: - binds bacterial cell wall resulting in altered osmotic homeostasis & cell death

Related

gingivitis

General

topical antiseptic

Properties

Database Correlations

PUBCHEM correlations

References

  1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Deprecated Reference
  4. Noto MJ et al Chlorhexidine Bathing and Health Care-Associated Infections. A Randomized Clinical Trial; JAMA. Published online January 20, 2015 PMID: 25602496 http://jama.jamanetwork.com/article.aspx?articleid=2091544 - Pittet D, Angus DC Daily Chlorhexidine Bathing for Critically Ill Patients. A Note of Caution. JAMA. Published online January 20, 2015. PMID: 25603492 http://jama.jamanetwork.com/article.aspx?articleid=2091541
  5. FDA Safety Alert. Feb 2, 2017 Chlorhexidine Gluconate: Drug Safety Communication - Rare But Serious Allergic Reactions. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm539575.htm

Component-of

acetic acid/chlorhexidine/ketoconazole ammonium chloride/benzalkonium/chlorhexidine chlorhexidine/climbazole chlorhexidine/cortisol chlorhexidine/cortisol/ketoconazole chlorhexidine/didecyldimethylammonium chloride chlorhexidine/ethanol chlorhexidine/isopropanol chlorhexidine/ketoconazole chlorhexidine/ketoconazole/salicyloyl phytosphingosine chlorhexidine/lidocaine chlorhexidine/lidocaine/pramoxine chlorhexidine/miconazole chlorhexidine/miconazole/nitrate chlorhexidine/salicylic acid