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Heyde syndrome

Pathology: - bleeding gastrointestinal angioectasias in patients with aortic valvular stenosis - normally asymptomatic gastrointestinal angioectasias bleed due to mechanical disruption of vWF multimers during turbulent flow through a stenotic aortic valve in patients with severe aortic valvular stenosis - secondary von Willebrand's disease results with GI bleed from gastrointestinal angioectasias Management: - aortic valve replacement

General

syndrome aortic valvular stenosis (AS) gastrointestinal angioectasia

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012
  2. Gola W, Lelonek M. Clinical implication of gastrointestinal bleeding in degenerative aortic stenosis: an update. Cardiol J. 2010;17(4):330-4. PMID: 20690087
  3. Loscalzo J From Clinical Observation to Mechanism - Heyde's Syndrome. N Engl J Med 2012; 367:1954-1956. November 15, 2012 PMID: 23150964 http://www.nejm.org/doi/full/10.1056/NEJMcibr1205363
  4. Vincentelli A, Susen S, Le Tourneau T et al Acquired von Willebrand Syndrome in Aortic Stenosis. N Engl J Med 2003; 349:343-349. July 24, 2003 PMID: 12878741 Free Article http://www.nejm.org/doi/full/10.1056/NEJMoa022831