Search
homeobox protein PRH; hematopoietically-expressed homeobox protein HHEX; homeobox protein HEX (PRH, HHEX, HEX, PRHX)
Function:
- recognizes the DNA sequence 5'-ATTAA-3'
- transcriptional repressor
- may play a role in hematopoietic differentiation
- establishes anterior identity at two levels
a) acts early to enhance canonical WNT-signaling by repressing expression of TLE4
b) acts later to inhibit NODAL-signaling by directly targeting NODAL
Structure: contains 1 homeobox DNA-binding domain
Compartment: nucleus (probable)
Expression:
- expressed in liver & promyelocytic leukemia cell line HL60
- expressed during hematopoiesis
General
homeobox protein
Properties
SIZE: entity length = 270 aa
MW = 30 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 1-133
MOTIF: proline residue (SEVERAL)
homeodomain
SITE: 137-196
Database Correlations
OMIM 604420
UniProt Q03014
Pfam PF00046
Kegg hsa:3087
References
UniProt :accession Q03014