transcription factor HES-2 (hairy & enhancer of split 2, HES2)

Function: - transcriptional repressor of genes that require a bHLH protein for their transcription Structure: - contains 1 basic helix-loop-helix domain (bHLH) - contains 1 Orange domain - has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) - C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins Compartment: nucleus Alternative splicing: named isoforms=2 Expression: expressed in placenta Pathology: - expressed in pancreatic cancer, colon cancer with RER, cervical cancer, head & neck cancers

General

hairy & enhancer of split (HES) transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 18 kD entity length = 173 aa COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 13-26 helix-loop-helix NAME: helix-loop-helix SITE: 27-71 FOR-BINDING-VIA: helix-loop-helix Orange {86-119} proline-rich region SITE: 139-167 MOTIF: proline residue (SEVERAL) WRPW {170-173}

Database Correlations

UniProt Q9Y543 PFAM correlations

References

UniProt :accession Q9Y543