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Herpes zoster subunit vaccine
Dosage:
- two doses were given 2 months apart
Mechanism of action:
- contains varicella zoster virus glycoprotein E plus an adjuvant
Notes:
- high efficacy in older adults [1]
- 97% efficacy, with similar benefits across age groups [1]
- cost effective in older adults [2]
General
Herpes zoster (shingles) vaccine (Zostavax, Shingrix)
References
- Lal H et al
Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in
Older Adults.
N Engl J Med. April 28, 2015
PMID: 25916341
http://www.nejm.org/doi/full/10.1056/NEJMoa1501184
- Le P, Rothberg, MB
Cost-effectiveness of the Adjuvanted Herpes Zoster Subunit
Vaccine in Older Adults.
JAMA Intern Med. Published online January 2, 2018.
PMID: 29297049
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2666789
- Najafzadeh M.
Evolution of Herpes Zoster Vaccines and Their Economic Value.
JAMA Intern Med. Published online January 2, 2018
PMID: 29297047
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2666787