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human herpesvirus type 8; Kaposi's sarcoma-associated herpesvirus (HHV8, KSVK)
Etiology:
- men who have sex with men with AIDS
Pathology:
- associated with Kaposi's sarcoma
- HHV-8 is also found in body cavity-based non-Hodgkin's lymphoma in patients with AIDS
- the HHV-8 virus is found frequently in saliva
- in-situ hybridization studies show the virus localized to epithelial cells in the buccal mucosa [2]
- Castleman's disease
- virus latent in B-lymphocytes, endothelial cells
Clinical manifestations:
- painless violaceous skin nodules
- nodules in the mouth
Laboratory:
- Herpes virus 8 serology
- Herpes virus 8 DNA
- Herpes virus 8 latent nuclear antigen in tissue
- see ARUP consult [3]
Management:
- antiretroviral therapy
- treatment of Kaposi's sarcoma
Related
gammaherpesvirinae
Herpes virus 8 DNA
Kaposi's sarcoma
General
herpesviridae
oncogenic virus
Properties
KINGDOM: virus
GENOME-TYPE: deoxyribonucleic acid (DNA)
DOUBLE-STRANDED
GENOME-SIZE: entity length
:VALUE RANGE
:LOW 120
:HIGH 200
:UNITS KB
ENVELOPE: PRESENT
CAPSID-SYMMETRY: ICOSAHEDRAL
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, 17, 18.
American College of Physicians, Philadelphia 1998, 2015, 2018.
- Journal Watch 21(1):1, 2001
Pauk J, Huang ML, Brodie SJ et al
Mucosal shedding of human herpesvirus 8 in men.
N Engl J Med. 2000 Nov 9;343(19):1369-77
PMID: 11070101
- Moore PS.
The emergence of Kaposi's sarcoma-associated herpesvirus
(human herpesvirus 8).
N Engl J Med 343:1411, 2000
PMID: 11070109
- ARUP Consult: Human Herpesvirus 8 - Kaposi Sarcoma
The Physician's Guide to Laboratory Test Selection & Interpretation
https://www.arupconsult.com/content/kaposi-sarcoma
- De Paoli P, Carbone A.
Kaposi's Sarcoma Herpesvirus: twenty years after its discovery.
Eur Rev Med Pharmacol Sci. 2016 Apr;20(7):1288-94. Review.
PMID: 27097948 Free ArticleDe Paoli P, Carbone A.
Kaposi's Sarcoma Herpesvirus: twenty years after its discovery.
Eur Rev Med Pharmacol Sci. 2016 Apr;20(7):1288-94. Review.
PMID: 27097948 Free Article