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HECT domain & RCC1-like domain-containing protein 2 (HERC2)
Structure:
- contains 1 cytochrome b5 heme-binding domain
- contains 1 HECT domain
- contains 1 MIB/HERC2 domain
- contains 19 RCC1 repeats
- contains 6 WD repeats
- contains 1 ZZ-type zinc finger
General
zinc finger protein
Properties
SIZE: MW = 527 kD
entity length = 4834 aa
MOTIF: WD repeat {2-46}
WD repeat {286-327}
WD repeat {490-529}
RCC1 repeat {513-568}
RCC1 repeat {569-620}
RCC1 repeat {623-674}
RCC1 repeat {675-726}
WD repeat {704-743}
RCC1 repeat {728-778}
coiled coil {948-980}
heme-binding site [1207-1283]
C2 domain {1870-1932}
MOTIF: binding site
FOR-BINDING-OF: phospholipid
Ca+2-binding site
Zn finger ZZ-type
NAME: Zn finger ZZ-type
SITE: 2702-2749
EFFECTOR-BOUND: Zn+2
RCC1 repeat {2958-3009}
RCC1 repeat {3010-3064}
RCC1 repeat {3065-3116}
RCC1 repeat {3118-3168}
RCC1 repeat {3171-3222}
RCC1 repeat {3224-3274}
RCC1 repeat {3275-3326}
WD repeat {3926-3967}
RCC1 repeat {3951-4002}
RCC1 repeat {4004-4056}
RCC1 repeat {4058-4108}
RCC1 repeat {4110-4162}
RCC1 repeat {4164-4214}
RCC1 repeat {4216-4266}
WD repeat {4241-4283}
RCC1 repeat {4268-4318}
HECT {4457-4794}
Database Correlations
OMIM 605837
UniProt O95714
PFAM correlations
References
UniProt :accession O95714