Search
hepsin; serine protease hepsin; transmembrane protease serine 1 (HPN, TMPRSS1)
Function:
- role in cell growth & maintenance of cell morphology
- cleavage after basic amino-acid residues, with Arg strongly preferred to Lys
Structure:
- belongs to the peptidase S1 family
- contains 1 peptidase S1 domain
- contains 1 SRCR domain
Compartment: membrane
Expression:
- present in most tissues
- highest level in liver
Pathology:
- expressed in high levels in malignant prostate tissue, but absent in metastatic tissue
General
serine protease trypsin family
Properties
SIZE: entity length = 417 aa
MW = 45 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {24-44}
SRCR {54-151}
MOTIF: cysteine residue {C77}
MODIFICATION: cysteine residue {C140}
cysteine residue {C90}
MODIFICATION: cysteine residue {C150}
N-glycosylation site {N112}
cysteine residue {C119}
MODIFICATION: cysteine residue {C138}
cysteine residue {C138}
MODIFICATION: cysteine residue {C119}
cysteine residue {C140}
MODIFICATION: cysteine residue {C77}
cysteine residue {C150}
MODIFICATION: cysteine residue {C90}
cysteine residue {C153}
MODIFICATION: cysteine residue {C-INTERCHAIN}
S1 domain {163-405}
MOTIF: cysteine residue {C188}
MODIFICATION: cysteine residue {C204}
histidine residue {H203}
cysteine residue {C204}
MODIFICATION: cysteine residue {C188}
aspartate residue {D257}
cysteine residue {C291}
MODIFICATION: cysteine residue {C359}
cysteine residue {C322}
MODIFICATION: cysteine residue {C338}
cysteine residue {C338}
MODIFICATION: cysteine residue {C322}
cysteine residue {C349}
MODIFICATION: cysteine residue {C381}
serine residue {S353}
cysteine residue {C359}
MODIFICATION: cysteine residue {C291}
cysteine residue {C381}
MODIFICATION: cysteine residue {C349}
Database Correlations
OMIM 142440
UniProt P05981
PFAM correlations
Kegg hsa:3249
ENZYME 3.4.21.106
References
- UniProt :accession P05981
- Dhanasekaran et al
Delineation of prognostic markers in prostate cancer
Nature 412:822, 2001
PMID: 11518967