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hepatocyte
Physiology:
- human diploid hepatocytes turnover throughout life
- average age of human hepatocyte is 3 years
Pathology:
- polyploid* hepatocytes are compromised in their ability to divide
* transitions between diploid & polyploid hepatocytes are limited under homeostatic conditions
General
epithelial cell
References
- Heinke P, Rost F, Rode J et al
Diploid hepatocytes drive physiological liver renewal in adult humans.
Cell Systems 2022. May 31
PMID: 35649419
https://www.cell.com/cell-systems/fulltext/S2405-4712(22)00171-5
- De Simone V, De Magistris L, Lazzaro D, Gerstner J,
Monaci P, Nicosia A, Cortese R.
LFB3, a heterodimer-forming homeoprotein of the LFB1 family,
is expressed in specialized epithelia.
EMBO J. 1991 Jun;10(6):1435-43.
PMID: 1673925