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hepatitis G virus; GB virus C (GBV-C)
Originally isolated from hepatitis patients & called hepatitis G virus.
Epidemiology:
- transmitted parenterally, sexual transmission less common [3]
- 2% of US blood donors are colonized
Pathology:
does NOT cause hepatitis or any other known human disease
GBV-C appears to inhibit pathogenesis of HIV [3]
1) coinfection of HIV & GBV-C (vs infection with HIV alone)
a) affords a survival advantage
b) delays time to diagnosis of AIDS
2) plasma HIV viremia inversely correlated with GBV-C viremia
3) GBV-C suppresses HIV replication in vitro
Laboratory:
- Hepatitis G virus Ab in serum
- Hepatitis G virus RNA in serum
- 10 kB RNA virus
Related
hepatitis virus
viral hepatitis
General
flaviviridae
Properties
KINGDOM: virus
GENOME-TYPE: RNA
SINGLE-STRANDED
NEGATIVE-STRAND
GENOME-SIZE: 10 kB
ENVELOPE: PRESENT
CAPSID-SYMMETRY: ICOSAHEDRAL
References
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1066
- Journal Watch 21(20):159, 2001
Xiang et al NEJM 345:707, 2001
Tillmann et al NEJM 345:715, 2001
Stoso & Wolinsky, NEJM 345:761, 2001
- Ramezani A et al
Frequency of hepatitis G virus infection among HIV positive
subjects with parenteral and sexual exposure.
J Gastrointestin Liver Dis. 2008 Sep;17(3):269-72.
PMID: 18836618
- Shankar EM et al
GB virus infection: a silent anti-HIV panacea within?
Trans R Soc Trop Med Hyg. 2008 May 28. [Epub ahead of print]
PMID: 18513775
- Jung S,
HIV entry inhibition by the envelope 2 glycoprotein of GB
virus C.
AIDS. 2007 Mar 12;21(5):645-7.
PMID: 17314528
- Reshetnyak VI, Karlovich TI, Ilchenko LU.
Hepatitis G virus.
World J Gastroenterol. 2008 Aug 14;14(30):4725-34.
PMID: 18720531