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hepatitis C genotyping

Indications: - hepatitis C infection Reference interval: - test may be unsuccessful if HCV RNA viral load is < log 3.3 or 2000 IU/mL [2] Clinical significance: - hepatitis C infection is caused by one of 6 major gentotypes of hepatitis C virus (1-6) [2] - hepatitis C virus types 2 & 3 respond to lower doses & shorter duration of therapy with pegylated interferon-alpha than other types - hepatitis C virus type 1b responds poorly to therapy with pegylated interferon-alpha Method: - direct sequencing of 5' non-coding region - limitations in differentiating subtype 1a from 1b [2] - line probe analysis Specimen: - serum, plasma Notes: - Abbott RealTime HCV Genotype II can differentiate HCV genotypes 1, 1a, 1b, 2, 3, 4, & 5 [4]

Related

hepatitis C infection hepatitis C virus

General

genotyping (allele testing)

References

  1. Clinical Guide to Laboratory Tests, 4th edition, HB Wu ed, WB Saunders, Philadelphia, 2006
  2. HCV Genotyping By Sequencing Laboratory Test Directory ARUP: 55593
  3. Panel of 24 tests Laboratory Test Directory ARUP: 2004680
  4. FDA News Release: June 20, 2013 FDA approves first genotyping test for patients with hepatitis C virus http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm357982.htm