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hepatitis B virus (HBV)
Structure:
Hepatitis B viral particle:
1) HBsAg (surface antigen)
a) protein surface coat
b) spills into the circulation in great excess
c) earliest serum marker of hepatitis B (HBV) infection
d) disappears from serum after resolution of HBV infection
e) anti-HBsAg antibody is protective
2) HBcAg (viral core protein)
a) IgM antibody to HBcAg (IgM anti-HBc)
1] follows appearance of HBsAg in serum
2] marker of acute hepatitis B infection
b) IgG antibody to HBcAg (IgG anti-HBc)
- indicates recovery from acute infection
3) HBeAg
a) shares homology with HBcAg
b) presence in serum
1] correlates with infectivity
2] identifies candidates for interferon treatment of chronic hepatitis B infection
4) viral DNA polymerase
5) viral double-stranded DNA genome
Epidemiology:
HBV is infectious >= 1 month on a surface at room temperature [2]
Pathology:
- HBXAP facilitates transcription of hepatitis B virus (HBV) genes by the HBV pX transcription activator
- apparently highjacks cellular gamma-2-adaptin (AP1G2) during viral maturation
Laboratory:
- see ARUP consult [3]
Related
hepatitis B infection
hepatitis B virus (HBV) serology
hepatitis B virus DNA
Hepatitis B virus genotyping
hepatitis virus
General
hepadnaviridae
Properties
KINGDOM: virus
GENOME-TYPE: deoxyribonucleic acid (DNA)
DOUBLE-STRANDED
SINGLE-STRANDED
ENVELOPE: PRESENT
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, 2018.
American College of Physicians, Philadelphia 1998, 2018.
- Veterans Administration, Mather CA
- ARUP Consult: Hepatitis B Virus - HBV
The Physician's Guide to Laboratory Test Selection & Interpretation
https://www.arupconsult.com/content/hepatitis-b-virus
- Hepatitis B Virus Testing Algorithm
https://arupconsult.com/algorithm/hepatitis-b-virus-testing-algorithm