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exposure to hepatitis B virus

Laboratory: 1) see hepatitis B serology 2) HBcAb IgM & HBcAb total are indicators of hepatitis B exposure Management: - source tests positive for HBsAg - if exposed person has documented adequate HBsAb levels (>= 10 mIU/mL), no further treatment is necessary. - if not, HBIG: single dose of 0.06 mL/kg intramuscularly (IM) plus hepatitis B vaccine within 24 hours of exposure - HBIG is indicated if the source patient is positive for HBsAg & the exposed person is a vaccine nonresponder, is unvaccinated, or is incompletely vaccinated Notes: 1) exposure does not indicate active infection 2) HBsAb but not HBcAb total may be positive with immunization

Related

hepatitis B virus (HBV)

General

exposure to viral hepatitis

References

  1. Laboratory Medicine: Test Selection & Interpretation. Howanitz & Howanitz (eds), Churchill Livingstone, NY, 1991, pg 818-19
  2. Medical Knowledge Self Assessment Program (MKSAP) 15, 18 American College of Physicians, Philadelphia 2009, 2018.