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hepatic triglyceride lipase; hepatic triacylglycerol lipase; HL; lipase member C (LIPC, HTGL)
Function:
- hepatic lipase functions to remove chylomicron remnants from circulation
- preferred substrate is phospholipid associated with HDL
- allegedly, activity negatively correlates with HDL levels
- capacity to catalyze hydrolysis of phospholipids, mono-, di-, & triglycerides, & acyl-CoA thioesters
- attachment to cell surface proteoglycan is presumptive, presumed from release into plasma following heparin administration
- contributes to post-heparin lipolytic activity
triacylglycerol + H2O diacylglycerol + a carboxylate
Structure:
- belongs to the AB hydrolase superfamily, lipase family
- contains 1 PLAT domain
Compartment: secreted
Pathology:
- defects in LIPC are the cause of hepatic lipase deficiency
General
triglyceride lipase
Properties
SIZE: entity length = 499 aa
MW = 56 kD
COMPARTMENT: plasma membrane
CELL: hepatocyte
MOTIF: signal sequence {1-22}
N-glycosylation site {N42}
N-glycosylation site {N78}
serine residue {S168}
binding site
SITE: 181-193
EFFECTOR-BOUND: heparan sulfate proteoglycan
aspartate residue {D194}
histidine residue {H279}
PLAT {352-486}
MOTIF: N-glycosylation site {N362}
N-glycosylation site {N397}
Database Correlations
OMIM 151670
MORBIDMAP 151670
UniProt P11150
PFAM correlations
ENZYME 3.1.1.3
References
- Primary Hyperlipoproteinemias, Steiner & Shafrir
(eds), McGraw Hill, NY, 1991, pg 29
- Brouwer et al Am J Clin Nutr 57:533 1993
- SHMPD, The Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LIPC
- UniProt :accession P11150