hemosiderin

Hemosiderin is aggregated, partially deproteinized ferritin which together within ferritin account for the bulk of total body iron stores. In contrast to ferritin, hemosiderin is insoluble in aqueous solutions. Release of Fe(II) from ferritin is much faster than release from hemosiderin. Like ferritin, hemosiderin is found predominantly in cells of the liver, spleen, & bone marrow. Laboratory: - hemosiderin in specimen - hemosiderin in serum - hemosiderin in sputum - hemosiderin in urine

Properties

GENERAL: ferritin RELATED: hemosiderin laden macrophage SIZE: MW = 460 kD COMPARTMENT: plasma MOTIF: Iron [Fe]-binding site (4500) EFFECTOR-BOUND: FE[O{H2PO4}] SUBUNITS: ferritin heavy chain (12) MOTIF: Ferritin-like diiron {11-160} MOTIF: Iron [Fe]-binding site SITE: 28-28 Iron [Fe]-binding site SITE: 63-63 Iron [Fe]-binding site SITE: 66-66 Iron [Fe]-binding site SITE: 108-108 Iron [Fe]-binding site SITE: 142-142 Ser phosphorylation site {S179} ferritin light chain (12) MOTIF: Ferritin-like diiron {7-156} MOTIF: active site SITE: 54-61 Iron [Fe]-binding site SITE: 54-54 Iron [Fe]-binding site SITE: 57-57 Iron [Fe]-binding site SITE: 58-58 Iron [Fe]-binding site SITE: 61-61 Iron [Fe]-binding site SITE: 64-64

References

Loinc