hemoglobin Barts

Pathology: 1) has essentially no oxygen carrying capacity 2) associated with homozygous alpha thalassemia

Properties

GENERAL: hemoglobin-variant RELATED: alpha thalassemia-0 COMPARTMENT: cytoplasm CELL: erythrocyte SUBUNITS: hemoglobin gamma chain (4) MOTIF: heme-binding site COFACTOR-BOUND: heme{FE+2} FOR-BINDING-OF: O2

References

Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 649