Search
hemoglobin A2 in blood
Indication:
- evaluation of hemoglobinopathy
Normal range: 1.5-3.5%
Clinical significance:
- contribution to total hemoglobin increases with defects in hemoglobin beta-chain (beta-thalassemia)
Increases:
1) beta thalassemia (trait: 3.7-7%)
2) drug-induced megaloblastic anemia
3) hemoglobinopathy (values in excess of 10%)
a) hemoglobin C
- hemoglobin SC (50%)
b) hemoglobin E
c) hemoglobin O
Decreases:
1) untreated iron deficiency
2) erythroleukemia
3) hemoglobin H disease
4) delta-thalassemia
Specimen:
1) hemolysate prepared from whole blood (EDTA, heparin, oxalate)
2) stable for 30 days at 4 degrees C
Related
hemoglobin A2
General
hemoglobin subtype in blood
References
- Clinical Diagnosis & Management by Laboratory Methods,
J.B. Henry (ed), W.B. Saunders Co., Philadelphia,
PA. 1991, pg 646
- Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz
ed, WB Saunders, Philadelphia, 1995
- Panel of 10 tests
Laboratory Test Directory ARUP: 50610
- Panel of 3 tests
Laboratory Test Directory ARUP: 50613
- Panel of 10 tests
Laboratory Test Directory ARUP: 2005792