Search
heme oxygenase-1 (HMOX1, heat shock protein 32, HO1)
Function:
- in association with cyt P450 reductase & bilirubin reductase, cleaves heme to form bilirubin, CO & Fe+2
- electrons donated by cyt P450 reductase
- biliverdin reductase rapidly reduces biliverdin to bilirubin
heme oxygenase
cyt P450 reductase
heme[Fe+2] + O2 ------------------> biliverdin + CO + Fe+2
+ NADPH + H+ + NADP+ + H2O
biliverdin reductase
biliverdin ------------------> bilirubin + NADP+
+ NADPH + H+
Structure: belongs to the heme oxygenase family
Compartment: microsome
Expression:
- found especially in spleen & other peripheral tissues associated with destruction of erythrocytes
- highly inducible by its substrate heme & by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents & UVA
- inducible by stress, including inflammation & heat shock
Related
heme
heme catabolism
heme oxygenase 1 gene
General
heat shock protein
heme oxygenase
Properties
SIZE: entity length = 288 aa
MW = 33 kD
COMPARTMENT: smooth endoplasmic reticulum
CELL: macrophage
WITHIN: spleen
MOTIF: Iron [Fe]-binding site
SITE: 25-25
active site
Ser phosphorylation site {S229}
Database Correlations
OMIM 141250
UniProt P09601
Pfam PF01126
Kegg hsa/hsa00860
ENZYME 1.14.99.3
References
- Snyder SH.
Nitric oxide: first in a new class of neurotransmitters.
Science. 1992 Jul 24;257(5069):494-6. Review.
PMID: 1353273
- Smith MA, Kutty RK, Richey PL, Yan SD, Stern D, Chader GJ,
Wiggert B, Petersen RB, Perry G.
Heme oxygenase-1 is associated with the neurofibrillary
pathology of Alzheimer's disease.
Am J Pathol. 1994 Jul;145(1):42-7.
PMID: 8030754 1994
- Sedlak TW, Snyder SH.
Messenger molecules & cell death: therapeutic implications.
JAMA. 2006 Jan 4;295(1):81-9.
PMID: 16391220
- UniProt :accession P09601
Component-of
multienzyme complex