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heme oxygenase
Function:
- in association with cyt P450 reductase & bilirubin reductase, cleaves heme to form bilirubin, CO & Fe+2
- electrons donated by NADPH via cyt P450 reductase
- biliverdin reductase rapidly reduces biliverdin to bilirubin
heme oxygenase
cyt P450 reductase
heme[Fe+2] + O2 ------------------> biliverdin + CO + Fe+2
+ NADPH + H+ + NADP+ + H2O
biliverdin reductase
biliverdin ------------------> bilirubin + NADP+
+ NADPH + H+
Related
heme
heme catabolism
Specific
heme oxygenase-1 (HMOX1, heat shock protein 32, HO1)
heme oxygenase-2 (HMOX2, HO-2)
General
hydroxylase; monooxygenase
Properties
COMPARTMENT: smooth endoplasmic reticulum
MOTIF: active site
Database Correlations
ENZYME 1.14.99.3
References
- Snyder SH.
Nitric oxide: first in a new class of neurotransmitters.
Science. 1992 Jul 24;257(5069):494-6. Review.
PMID: 1353273
- Sedlak TW, Snyder SH.
Messenger molecules & cell death: therapeutic implications.
JAMA. 2006 Jan 4;295(1):81-9.
PMID: 16391220