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hematopoiesis
The formation & development of blood cells, including:
1) erythrocytes (erythropoiesis)
2) neutrophils
3) monocytes
4) eosinophils
5) basophils
6) lymphocytes
7) platelets
In adults, hematopoiesis is restricted to the pelvis, sternum & vertebrae.
Physiology:
- hematopoiesis in adults <65 years of age is massively polyclonal [2]
- in adults >75 years, 30-60% of haematopoiesis is accounted for by 12-18 independent clones, each contributing 1-34% of blood production [2]
- most clones had begun their expansion before age 40 years
- only 22% with known driver mutations
- loss of the Y chromosome confers a selective benefits in males
Related
age-associated changes in hematopoiesis
hematopoietic system
Specific
erythropoiesis
leukocyte differentiation
leukopoiesis
megakaryocytopoiesis
thrombopoiesis; thrombocytopoiesis
General
genesis
cellular differentiation
References
- Stedman's Medical Dictionary 27th ed, Williams &
Wilkins, Baltimore, 1999
- Mitchell E, Spencer Chapman M, Williams N et al.
Clonal dynamics of haematopoiesis across the human lifespan.
Nature 2022. 606, 343-350
PMID: 35650442 PMCID: PMC9177428 Free PMC article
https://www.nature.com/articles/s41586-022-04786-y