Search
hemangiopericytoma of meninges
Pathology:
1) aggressive malignancy of meningeal origin
Microscopic pathology: see hemangiopericytoma for images
1) characteristic 'staghorn' vascular spaces or numerous small slit-like vascular spaces lined by flattened endothelial cells
2) highly cellular, monotonous, randomly oriented plump cells with scant ill-defined cytoplasm
3) dense network of reticulin fibers Immunohistochemsitry:
- vimentin ~85% +
- factor XIIIa ~80% +
- leu-7 ~70% +
- CD34 variable % +
Management:
Prognosis:
- tendency to recur & metastasize; generally regarded as malignant although some are less aggressive.
- corresponds to WHO histological grade II or III.
General
hemangiopericytoma
meningeal neoplasm
References
- WHO Classification Tumours of the Nervous System.
Kleihues & Cavenee eds. IARC Press 2000
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 2403