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helper T cell (T4 lymphocyte, CD4+)

Charascteristics: - T4 (CD3, CD4)+ lymphocyte. - development of immature T-cell precursors (thymocytes) to CD4 helper T-cells correlates with T-cell receptor specificity for major histocompatibility complex class 2 molecules. - ZNF67 expression is necessary & sufficient for commitment of CD4+ cell lineage Normally 60% of circulating lymphocytes. Normal range: 1000-2300/uL in peripheral blood. Pool size: 2 x 10E11 1/2 life 156 days Cytokines produced by both Th1 & Th2 T-helper cells 1) GM-CSF 2) IL-2 3) IL-3 4) IL-10 5) IL-13

Related

CD4 cells in blood; CD3+CD4+ T-helper cells in blood CD4/CD8 ratio CD4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3 granulocyte-macrophage colony-stimulating factor; GM-CSF; colony-stimulating factor 2; molgramostin; sargramostim (CSF2, GMCSF) interleukin-10; IL-10; cytokine synthesis inhibitory factor; CSIF (IL10) interleukin-13 (IL13, IL-13, NC30) interleukin-2; IL-2; T-cell growth factor; TCGF (IL2) interleukin-3; erythrocyte burst-promoting factor; hematopoietic growth factor; mast-cell colony-stimulating factor; multipotential colony-stimulating factor; colony-stimulating factor-2 alpha; mast cell growth factor; P-cell stimulating factor (IL3, IL-3)

Specific

T helper 0 (Tho) T helper 1 (Th1) T helper 17 (Th17) T helper 2 (Th2) cell

General

T lymphocyte (T-cell, thymocyte)

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  2. Williams Hematology, 5th ed, Beutler et al (eds), McGraw Hill, NY, 1995, pg 965
  3. Murasko DM & Berstein ED, Immunology of Aging, In: Principles of Geriatric Medicine, 4th ed,, Hazzard et al (eds), McGraw-Hill, NY, 1999, pg 99