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Helicobacter pylori (H pylori) antibody in serum

Indications: - H pylori infection - peptic ulcer disease Contraindications: - not routinely indicated for GERD Procedure: ELISA: detects IgG or IgA antibodies to H pylori Sensitivity: 90-100% Specificity: 76-96% Accuracy: 83-98% Testing may be less specific in the elderly. [2] Post eradication: 1) at 3 months H pylori titers decrease by 50% 2) at 18 months, 60% of patients have undetectable H pylori antibodies Notes: - not affected by recent gastrointestinal bleeding or the use of proton pump inhibitors [3]

Specific

Helicobacter pylori IgA in serum Helicobacter pylori IgG in serum Helicobacter pylori IgM in serum

General

Helicobacter pylori antibody

References

  1. UpToDate 2004 http://www.uptodate.com
  2. Liston R et al, Lancet 347:269, 1996
  3. Medical Knowledge Self Assessment Program (MKSAP) 16, 17 American College of Physicians, Philadelphia 2012, 2015