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heat shock transcription factor 4; heat shock factor protein 4 (HSF4, HSTF4, hHSF4)
Function:
- DNA-binding protein, constitutive DNA binding
- specifically binds heat shock promoter elements (HSE)
- forms trimers even in the absence of stress
- isoform HSF4A represses transcription, while isoform HSF4B activates transcription
- phosphorylated on Ser & Thr residues by MAPK1, MAPK2 & MAPK8
- interacts with DUSP26, MAPK1, MAPK2 & MAP kinase p38
Structure:
- homotrimer
- belongs to the HSF family
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- expressed in heart, skeletal muscle, eye & brain >> other tissues
Pathology:
- defects in HSF4 are the cause of lamellar cataract
General
heat shock factor
Properties
CONFIGURATION: trimer
SIZE: entity length = 493 aa
MW = 53 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 18-122
domain {130-204}
DUSP26/MAPK1/MAPK2 interaction {246-323}
HR-C {365-390}
Database Correlations
OMIM correlations
MORBIDMAP 602438
UniProt Q9ULV5
Pfam PF00447
Entrez Gene 3299
Kegg hsa:3299
References
UniProt :accession Q9ULV5