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head & neck squamous cell carcinoma

see head & neck cancer Pathology: - 95% of head & neck cancers are squamous cell carcinomas Genetics: - human-papillomavirus-associated tumours - helical domain mutations of the oncogene PIK3CA - alterations involving loss of TRAF3 - amplification of the cell cycle gene E2F1 [1] Laboratory: - breath analysis using mass spectroscopy for non-invasive diagnosis of early-stage head & neck squamous cell carcinoma [1] - TRAF3 gene mutation

General

head & neck cancer (HNC) squamous cell carcinoma (SCC)

References

  1. Mason H Head and Neck Cancer - Health Professional version A Breath Test to Diagnose Head and Neck Cancer. Medscape - Sep 22, 2020. https://www.medscape.com/viewarticle/937805 - Dharmawardana N, Goddard T, Woods C et al Development of a non-invasive exhaled breath test for the diagnosis of head and neck cancer. Br J Cancer 2020. Sept 9 PMID: 32901136 https://www.nature.com/articles/s41416-020-01051-9