Search
hepatocellular carcinoma-down-regulated mitochondrial carrier protein; solute carrier family 25 member 47 (SLC25A47, C14orf68, HDMCP, HMFN1655)
Function:
- uncoupling protein
- may catalyze the physiological 'proton leak' in liver mitochondrial electron transport
- overexpression induces dissipation of mitochondrial membrane potential
Structure:
- belongs to the mitochondrial carrier family
- contains 3 Solcar repeats
Compartment: mitochondrial inner membrane
Alternative splicing: named isoforms=2
Expression: specifically expressed in liver
Pathology: down-regulated in hepatocarcinoma
General
mitochondrial membrane protein
transmembrane 6 protein
Properties
SIZE: MW = 33 kD
entity length = 308 aa
COMPARTMENT: mitochondria
MOTIF: consensus repeat {1-80}
SEQUENCE-IS: Solcar
MOTIF: transmembrane domain {3-23}
transmembrane domain {49-69}
consensus repeat {93-206}
SEQUENCE-IS: Solcar
MOTIF: transmembrane domain {98-116}
transmembrane domain {190-210}
consensus repeat {215-302}
SEQUENCE-IS: Solcar
MOTIF: transmembrane domain {217-237}
transmembrane domain {273-293}
Database Correlations
OMIM 609911
UniProt Q6Q0C1
Pfam PF00153
Entrez Gene 283600
Kegg hsa:283600
References
UniProt :accession Q6Q0C1