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high density lipoprotein-2 (HDL-2)
HDL2 seems to be the mature HDL form. It is formed from HDL3 in the periphery. It is larger & contains more lipid than HDL3 (60 vs. 45%). Larger, more buoyant, HDL2 particles, but not HDL3 particles appear to have anti-atherogenic properties [2].
Properties
GENERAL: high density lipoprotein
COMPONENTS: apolipoprotein A1
MOTIF: signal sequence {1-18}
consensus repeat {68-89}
consensus repeat {90-111}
consensus repeat {112-122}
consensus repeat {123-144}
consensus repeat {145-166}
consensus repeat {167-188}
consensus repeat {189-210}
MOTIF: Ser phosphorylation site {S191}
consensus repeat {211-232}
consensus repeat {233-243}
consensus repeat {244-267}
apolipoprotein A2
MOTIF: signal sequence {1-18}
cysteine residue {C29}
MODIFICATION: cysteine residue {C136 IN APOD); IN HETERODIMERIC FORM}
cysteine residue {C29}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Ser phosphorylation site {S32}
Ser phosphorylation site {S35}
Ser phosphorylation site {S68}
apolipoprotein C
MOTIF: binding site
FOR-BINDING-OF: lipid
apolipoprotein E
MOTIF: signal sequence {1-18}
consensus repeat {80-101}
consensus repeat {102-123}
consensus repeat {124-145}
consensus repeat {146-167}
Ser phosphorylation site {S147}
LDL receptor binding {158-168}
MOTIF: binding site
SITE: 162-165
FOR-BINDING-OF: heparin
consensus repeat {168-189}
consensus repeat {190-211}
consensus repeat {212-233}
Thr glycosylation site {T212}
binding site
SITE: 229-236
FOR-BINDING-OF: heparin
consensus repeat {234-255}
Thr glycosylation site {T307}
Ser glycosylation site {S308}
SECRETED-BY: hepatocyte
astrocyte
WITHIN: central nervous system
Clusterin
MOTIF: signal sequence {1-22}
nuclear translocation signal {78-81}
N-glycosylation site {N86}
cysteine residue {C102}
MODIFICATION: cysteine residue {C-INTERCHAIN}
N-glycosylation site {N103}
cysteine residue {C113}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C116}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C121}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C129}
MODIFICATION: cysteine residue {C-INTERCHAIN}
N-glycosylation site {N145}
N-glycosylation site {N291}
N-glycosylation site {N317}
N-glycosylation site {N354}
N-glycosylation site {N374}
Thr phosphorylation site {T393}
Ser phosphorylation site {S394}
Ser phosphorylation site {S396}
nuclear translocation signal {443-447}
INHIBITS: protease
cholesterol
cholesterol ester
triglyceride
phosphatidyl choline
SIZE: MW = 360 kD
COMPARTMENT: plasma
FORM: hdl2
MISC-INFO: 1/2life 4 DAYS
References
- Tietz Textbook of Clinical Chemistry, 2nd ed.
Burtis CA & Ashwood ER (eds), WB Saunders Co,
Philadelphia PA, 1993, pg 1028
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998