histone deacetylase 9 (HD9, HD7B, HD7, histone deacetylase-related protein, MEF2-interacting transcription repressor MITR, HDAC9, HDAC7, HDAC7B,, HDRP KIAA0744, MITR)

Function: - see histone deacetylase - deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4) - represses MEF2-dependent transcription - isoform 3, called MITR/HDRP, lacks active site residues & therefore is catalytically inactive - represses MEF2-dependent transcription by recruiting HDAC1 &/or HDAC3 - seems to inhibit skeletal myogenesis & to be involved in heart development - protects neurons from apoptosis, both by inhibiting c-Jun phosphorylation by MAPK10 & by repressing c-Jun transcription via HDAC1 recruitment to c-Jun promoter - phosphorylated on Ser-220 & Ser-450, which a) promotes 14-3-3- binding b) impairs interaction with MEF2 c) antagonizes antimyogenic activity - phosphorylated on Ser-240, which impairs nuclear accumulation (putative) - isoform 7 is phosphorylated on Tyr-1010 - phosphorylated on Tyr-1007 (probable) - phosphorylated on Tyr-966 (probable) - phosphorylated on Tyr-1010 - does not interact with ETV6 - sumoylated - interacts with CTBP1 - phosphorylated form interacts with 14-3-3 (putative) - interacts with HDAC1 & HDAC3, & probably with HDAC4 & HDAC5 - interacts with MEF2, MAPK10, ETV6, NCOR1 & BCL6 Inhibition: - inhibited by trichostatin A (TSA) & suberoylanilide hydroxamic acid Structure: - homodimer - belongs to the histone deacetylase family, type 2 subfamily Compartment: nucleus (putative) Alternative splicing: - named isoforms=7 - additional isoforms seem to exist Expression: - broadly expressed - highest levels in brain, heart, muscle & testis - isoform 3 is present in human bladder carcinoma cells (at protein level) - chromosomal translocation t(1;7)(q41;p21) involving HDAC9 with TGFB2 is found in a family with Peters anomaly

General

histone deacetylase phosphoprotein

Properties

SIZE: entity length = 1011 aa MW = 111 kD COMPARTMENT: cell nucleus MOTIF: CTBP1 interaction {23-27} MEF2 interaction {136-154} MAPK10 interaction {175-343} MOTIF: ETV6 interaction {218-261} Ser phosphorylation site {S220} Ser phosphorylation site {S240} Ser phosphorylation site {S451} Histone deacetylase {631-978} MOTIF: histidine residue {H783}

Database Correlations

UniProt Q9UKV0 Entrez Gene 9734

References

UniProt :accession Q9UKV0