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histone deacetylase 6 (HDAC6)
Function:
- see histone deacetylase
- deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4)
- role in microtubule-dependent cell motility via deacetylation of tubulin
- interacts with CBFA2T3, HDAC11 & SIRT2
- interacts with F-actin
- ubiquitinated
- polyubiquitination does NOT lead to its degradation
- sumoylated in vitro
Structure:
- belongs to the histone deacetylase family, type 2 subfamily
- contains 1 UBP-type Zn+2 finger
Compartment:
- nucleus, cytoplasm
- mainly cytoplasmic, where it is associated with microtubules
General
histone deacetylase
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 1215 aa
MW = 131 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S22}
Thr phosphorylation site {T30}
Histone deacetylase 1 {87-404}
MOTIF: histidine residue {H216}
Histone deacetylase 2 {482-800}
MOTIF: histidine residue {H611}
Zinc finger
NAME: Zinc finger
SITE: 1131-1192
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 300272
UniProt Q9UBN7
PFAM correlations
Entrez Gene 10013
References
UniProt :accession Q9UBN7