histone deacetylase 5 (HD5, antigen NY-CO-9, HDAC5 KIAA0600)

Function: - see histone deacetylase - deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4) - involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C - during muscle differentiation, shuttles into the cytoplasm, allowing expression of myocyte enhancer factors - interacts with BCOR, HDAC7, HDAC9, CTBP1, MEF2C, NCOR2, NRIP1, PHB2 & a 14-3-3 chaperone protein - interacts with JARID1B - phosphorylated by CaMK at Ser-259 & Ser-498 - phosphorylation is required for the export to cytoplasm - ubiquitinated - polyubiquitination does NOT lead to its degradation Structure: - nuclear export sequence mediates shuttling between nucleus & the cytoplasm (putative) - belongs to the histone deacetylase family, type 2 subfamily Compartment: - nucleus, cytoplasm - shuttles between the nucleus & the cytoplasm - in muscle cells, shuttles into cytoplasm during myocyte differentiation - export to cytoplasm depends on interaction with a 14-3-3 chaperone protein & is its phosphorylation at Ser-259 & Ser-498 by CaMK Alternative splicing: named isoforms=2 Expression: ubiquitous

General

histone deacetylase phosphoprotein

Properties

SIZE: entity length = 1122 aa MW = 122 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: glycine-rich region {47-52} glutamine-rich region {85-92} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S259} Ser phosphorylation site {S498} glutamate-rich region {596-599} MOTIF: glutamate residue (SEVERAL) Histone deacetylase {684-1028} MOTIF: histidine residue {H833} nuclear export signal {1081-1122} MOTIF: alanine-rich region {1099-1104} MOTIF: alanine residue (SEVERAL)

Database Correlations

OMIM 605315 UniProt Q9UQL6 Entrez Gene 10014

References

UniProt :accession Q9UQL6