histone deacetylase 3 (HDAC3, HD3, RPD3-2, SMAP45)

Function: - see histone deacetylase - deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4) - probably participates in regulation of transcription through its binding to the Zn⁺²-finger transcription factor YY1 - increases YY1 repression activity - required to repress transcription of POU1F1 - interacts with HDAC7 & HDAC9 - forms a heterologous complex at least with YY1 - interacts with DAXX, HDAC10 & DACH1 - found in a complex with NCOR1 & NCOR2 - component of the N-Cor repressor complex - interacts with BCOR, MJD2A/JHDM3A, NRIP1 & SRY - interacts with BTBD14B - interacts with GLIS2 - interacts with CBFA2T3 - sumoylated in vitro Structure: - belongs to the histone deacetylase family, type 1 subfamily Compartment: nucleus Alternative splicing: named isoforms=2 Expression: widely expressed

Properties

SIZE: entity length = 428 aa MW = 49 kD COMPARTMENT: cell nucleus MOTIF: Histone deacetylase {3-316} MOTIF: histidine residue {H135}

Database Correlations

OMIM 605166 UniProt O15379 Pfam PF00850 Entrez Gene 8841

References

UniProt :accession O15379