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histone deacetylase 2 (HDAC2)

Function: - see histone deacetylase - deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4) - forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 & N-COR - interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1 - interacts with the non-histone region of H2AFY - part of the core histone deacetylase complex (HDAC complex) - component of BHC histone deacetylase complex - component of a mSin3A corepressor complex - part of a complex containing the core histones H2A, H2B, H3 & H4, DEK & unphosphorylated DAXX - part of a complex containing ATR & CHD4 - forms a heterologous complex at least with YY1 - interacts with ATR, DNMT1, MINT, HDAC7, HDAC10, HCFC1, NRIP1, MJD2A/JHDM3A, SAP30, SETDB1 & SUV39H1 - interacts with the non-histone region of H2AFY - interacts with PELP1 - interacts with CBFA2T3 - interacts with SAP30L Structure: - belongs to the histone deacetylase family, type 1 subfamily Compartment: nucleus Expression: - widely expressed - lower levels of expression in brain & lung Pathology: - in mice, HDAC2 impairs memory; inhibition of HDAC2 with vorinostat (Zolinza, SAHA) enhances memory [4] - higher levels of HDAC2 are found in hippocampus from Alzheimer's disease patients Pharmacology: - vorinostat (Zolinza, SAHA) inhibits HDAC2 - divalproex inhibits histone deacetylase (HDAC1, HDAC2, HDAC3 ?)

General

histone deacetylase phosphoprotein

Properties

SIZE: entity length = 488 aa MW = 55 kD COMPARTMENT: cell nucleus MOTIF: Histone deacetylase {9-322} MOTIF: histidine residue {H142} glycine-rich region {300-303} Ser phosphorylation site {S394} Ser phosphorylation site {S407} Ser phosphorylation site {S422} Ser phosphorylation site {S424}

References

  1. UniProt :accession Q92769
  2. Brehm et al Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597-601, 1998 PMID: 9468139
  3. Magnaghi-Jaulin L et al Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601-5, 1998 PMID: 9468140
  4. Guan J-S et al. HDAC2 negatively regulates memory formation and synaptic plasticity Nature 2009 May 7; 459:55. PMID: 19424149
  5. Graff J et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012 Mar 8; 483:222 PMID: 22388814

Component-of

histone deacetylase (HDAC) core complex

Databases & Figures

UniProt Q92769 Entrez Gene 3066 RB/E2F1 interactions